What Causes Schizophrenia? The American Journal of Psychiatry Provides an Answer

Bell%20curve I just read an interesting editorial in the current issue of The American Journal of Psychiatry on schizophrenia.  In particular this paragraph intrigued me:

"What causes schizophrenia? The short answer may be "nothing" or more precisely "no one thing." In most cases, schizophrenia is an end result of a complex interaction between thousands of genes and multiple environmental risk factors—none of which on their own causes schizophrenia. Daniel Weinberger, in his classic paper on brain development and schizophrenia , entertained the "unlikely" possibility that schizophrenia is "not the result of a discrete event or illness process at all, but rather one end of the developmental spectrum that for genetic and/or other reasons 0.5% of the population will fall into." Over 20 years later, this unlikely scenario is looking more realistic. Schizophrenia is increasingly considered a subtle neurodevelopmental disorder of brain connectivity, of how the functional circuits in our brains are wired. Schizophrenia may in fact be the tail end of a distribution of how the estimated 20 billion neurons and their trillions of synaptic connections in our brains are generated, eliminated, and maintained. Schizophrenia may be the uniquely human price we pay as a species for the complexity of our brain; in the end, more or less by genetic and environmental chance, some of us get wired for psychosis."

What strikes me is the characterization of schizophrenia as part of a developmental spectrum.  We've heard about the autistic spectrum, but very little about the schizophrenia spectrum.  In my book, Neurodiversity, I suggest that many neurodiverse conditions, including ADHD, dyslexia, mood disorders, anxiety disorders, and intellectual disabilities, form part of the continua for attention, literacy, mood, anxiety, and intelligence, respectively.  This is an important point, because it suggests that each one of us is somewhere on each of these spectra, and thus, in a way, linked to those whom we mistakenly believe are suffering from discrete "disorders" or "illnesses."

About the author

I am the author of 16 books including my latest: The Myth of the ADHD Child: 101 Ways to Improve Your Child's Behavior and Attention Span Without Drugs, Labels, or Coercion (Tarcher-Perigee). http://amzn.to/2ewwfbp.

Leave a Reply

Books by Dr. Armstrong

Article Archives